2x16GB vs 4x8GB RAM: 2x16GB is almost always fine now

2x16GB works on most modern motherboards unless you’re on a very old platform or a weird OEM board. The real issue isn’t support—it’s whether it’ll run at your desired speed, so check the QVL for that. The days of needing 4x8GB due to slot limitations are mostly over; that was a DDR3-era problem. Exceptions are rare, like older H310 chipsets capping at 8GB per slot.