2x16GB vs 4x8GB: 2x16GB is safer and simpler for RAM compatibility
2x16GB puts less strain on the memory controller, making it easier to hit rated speeds like 6000MHz DDR5 on consumer platforms. Four sticks are harder to stabilize with XMP/EXPO and can cause random crashes. If buying new, 2x16GB costs the same, leaves slots open for later, and saves you the headache.